Substitution at R3 having a halogen or alkoxy group (74f–74i) triggered a slight rise in mobile potency Along with the halide analogs (74g–h) exhibiting maximum the potency inside the group. Additional optimization triggered the discovery of 74i–j, with 74k as by far the most Energetic compound within the collection (pIC50 https://israellevky.gynoblog.com/30828565/the-ultimate-guide-to-indazole-fungicide