Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have identified recurrent mutations in genes regulating tumor mobile-microenvironment inte... https://elizabethn419enw6.corpfinwiki.com/user