Notice that under these instances there might be pain possibly without any stimulus or with an exceptionally gentle, non-tissue-damaging stimulus. It's important to point out that (1) there can be pain with out activity in Principal afferent nociceptors, and (2) there may be action in Principal afferent nociceptors without https://www.proleviate.com/post/conolidine-blocks-ackr3-pain-receptors-in-what-way