Chemotherapy was potentiated by E7449 and single agent had important antitumor action in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, very likely as a result of TNKS inhibition. Consistent with this risk, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization https://damienmboco.myparisblog.com/29865397/not-known-details-about-xp-59