At three times submit-MPTP, we found significant microglial activation and up-regulation of CB2 cannabinoid receptors within the ventral midbrain. Treatment method with WIN or maybe the CB2 receptor agonist JWH015 (four mg/kg, intraperitoneal) lessened MPTP-induced microglial activation, Whilst genetic ablation of CB2 receptors exacerbated MPTP systemic toxicity. Also, Continual Gain https://win55.clinic/tin-tuc